ChemicalBook CAS DataBase List 2,6-DICHLORO-4-NITROANISOLE

2,6-DICHLORO-4-NITROANISOLE synthesis

5synthesis methods

Product Name:2,6-DICHLORO-4-NITROANISOLE
CAS Number:17742-69-7
Molecular formula:C7H5Cl2NO3
Molecular Weight:222.03

3107-19-5 Synthesis

3107-19-5
179 suppliers
$5.00/1g

124-41-4 Synthesis

124-41-4
698 suppliers
$12.00/25g

17742-69-7
134 suppliers
$28.00/1 g

Yield: 98%

Reaction Conditions:

in methanol at 0 - 20; for 1.5 h;

Steps:

30.1; 31.1 Step 1: Example 30b
A mixture of Example 30a (2.1 g, 10 mmol) in MeOH (25 mL) was slowly added NaOMe (810 mg, 15 mmol) at 0°C. The reaction mixture was stirred at r.t. for 1.5 h. Water (50 mL) was added, and the mixture was extracted with EtOAc (100 mL*2). The combined organic layers were washed by brine (50 mL), separated, dried over Na₂S0₄ and filtered. The solvent was removed in reduced pressure to give the desired product Example 30b (2.18 g, yield 98%) as a white solid. *HNMR (400 MHz, CDCl₃) d 8.21 (s, 2H), 4.01 (s, 3H).

References:

FRONTHERA U.S. PHARMACEUTICALS LLC;JIN, Bohan;DONG, Qing;HUNG, Gene WO2019/240938, 2019, A1 Location in patent:Paragraph 00392; 00400