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37693-15-5

2,6-dichloro-4-nitro-m-cresol synthesis

3synthesis methods
-

Yield:37693-15-5 90%

Reaction Conditions:

with sulfuryl dichloride in acetic acid at 90; for 3 h;

Steps:

9.1 Step 1: Example 9b

A mixture of Example 9a (5.0 g, 32.6 mmol), sulfuryl dichloride (13.2 g, 97.7 mmol) in AcOH (50 mL) was heated to 90°C for 3 h under an inert atmosphere. This mixture was poured into H20, filtered, and the filter cake was washed with H20 twice, which was then dissolved in EtOAc, dried over Na2S04 and concentrated to give Example 9b (6.5 g, yield 90%) as a white solid. LCMS [M-l] = 219.9/221.9. NME (400 MHz, DMSO-r 6) d 8.04 (s, 1H), 2.46 (s, 3H).

References:

WO2019/240938,2019,A1 Location in patent:Paragraph 00298