ChemicalBook CAS DataBase List 2,6-Dichloro-3-fluoroacetophenone

2,6-Dichloro-3-fluoroacetophenone synthesis

3synthesis methods

Product Name:2,6-Dichloro-3-fluoroacetophenone
CAS Number:290835-85-7
Molecular formula:C8H5Cl2FO
Molecular Weight:207.03

877397-65-4 Synthesis

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol

877397-65-4
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290835-85-7
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$6.00/10g

Yield:290835-85-7 94.36%

Reaction Conditions:

with 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical;nitric acid in dimethyl sulfoxide at 30; for 35 h;Reagent/catalyst;Solvent;

Steps:

10; 11 Example 10:

In a 250 ml four-mouth flask equipped with mechanical stirring, (S)-1-(2,6-dichloro-3-fluorophenyl) ethanol 20g, dimethyl sulfoxide 60g, concentration of 65 ~ 68% nitric acid 0.50g, TEMPO (2,2,6,6-tetramethylpiopylidide) 0.50 g, stirred, vacuum, oxygen replacement, 35 h at 30 ° C, reactive, pyridine to the reaction bottle Adjusting the pH of 6 to 7, filtration, filtrate, adding drinking water, the aqueous layer is extracted with dichloromethane, combined with dichloromethane layer, distilled dichloromethane, heptane crystalline, collect 2,6-dichloro-3-fluorophenycelane 19.05 g, (yield 94.36%).

References:

CN113582901,2021,A Location in patent:Paragraph 0043-0046

756520-66-8 Synthesis