2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole synthesis
- Product Name:2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole
- CAS Number:106006-83-1
- Molecular formula:C7H11N3S
- Molecular Weight:169.25
104618-33-9
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Yield: 88.46%
Reaction Conditions:
with triethylamine;hydrazine in isopropyl alcohol for 2 - 3 h;Heating / reflux;
Steps:
5
100gm(0.3344mole) 2-amino-6-phthalimido-4,5,6,7-tetrahydro benzothiazole was suspended in 500ml isopropyl alcohol. Add 20.05gm(0.4010mole) hydrazine hydrate and 7.26gm (0.0718mole) Triethylamine. Reflux for 2-3hrs. Cool the mass to 10° C , Filter the slurry and wash with chilled isopropyl alcohol. Isolated mixture of compounds are recrystalize in absolute alcohol YIELD: 50gm(88.46%)
References:
ALEMBIC LIMITED WO2006/3677, 2006, A1 Location in patent:Page/Page column 10; 18
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