2,5-Dimethyl-1H-pyrrole synthesis

11synthesis methods

Product Name:2,5-Dimethyl-1H-pyrrole
CAS Number:625-84-3
Molecular formula:C6H9N
Molecular Weight:95.14

628-16-0 Synthesis

628-16-0
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$107.00/2g

625-84-3
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$17.67/5gm:

Yield:625-84-3 96%

Reaction Conditions:

with ammonia;AuC₂₇H₄₂N₂⁽¹⁺⁾*B(C₆F₅)4^(1-)=(AuC₂₇H₄₂N₂)(B(C₆F₅)4) in benzyl methyl ether;benzene-d6 at -60 - 135;Product distribution / selectivity;

Steps:

3

Example 3. Hydroamination of Allenes and Alkynes with Ammonia[0085] General Catalytic Procedure: The catalyst (15 mg) and the appropriate amount of alkyne or allene (see main Figure 2 for mol %) were loaded into a Wilmad QPV thick walled (1.4 mm) NMR tube. C₆D₆ (0.4 mL) and benzyl methyl ether (5 mg) as an internal standard were added to the mixture. For low catalyst loading (0.1 mol%) experiments, 3 mg of catalyst and 0.1 mL of C₆D₆ were used. The NMR tube was connected to a high vacuum manifold and excess NH₃ (typically 3-6 equivalents) was carefully condensed at -60 ⁰C. For experiments with 1,2-propadiene, the allene was first condensed with subsequent addition of NH₃. The tube was sealed and placed into an oil bath behind a blast shield, and heated at the specified temperature. ChemDraw Ultra 10.0 was utilized to name most of the compounds presented in example 3.

References:

WO2009/137810,2009,A2 Location in patent:Page/Page column 21; 2/13

625-86-5 Synthesis