2,5-Dimethoxy-Beta-Nitrostyrene synthesis
- Product Name:2,5-Dimethoxy-Beta-Nitrostyrene
- CAS Number:40276-11-7
- Molecular formula:C10H11NO4
- Molecular Weight:209.2
Yield:40276-11-7 71%
Reaction Conditions:
with ammonium acetate at 90; for 0.75 h;Microwave irradiation;Henry Nitro Aldol Condensation;
Steps:
4.1.2. General procedure for the synthesis of substituted β-nitrostyrenes,3a-3h
General procedure: β-Nitrostyrenes were synthesized using known procedures [62].Substituted aldehyde (1.0 mmol), nitro methane (1.5 mmol) andammonium acetate (0.8 mmol) were reacted using a Discover CEMmicrowave synthesizer (200 W, 20 psi, 30 s ramp time) at 90 C for 45min. Sealed microwave vessels (10 mL) were used in microwave-assistedorganic synthesis (MAOS). After completion of the reaction, the reactionmixture was cooled down and the formed crystals were filtered, washedwith methanol and recrystallized using methanol to give the β-nitrostyrenederivatives 3a-3h.
References:
de Silva, Nilamuni H.;Pyreddy, Suneela;Blanch, Ewan W.;Hügel, Helmut M.;Maniam, Subashani [Bioorganic Chemistry,2021,vol. 114,art. no. 105128] Location in patent:supporting information