2,5-DICHLOROBENZYLAMINE synthesis
- Product Name:2,5-DICHLOROBENZYLAMINE
- CAS Number:10224-70-1
- Molecular formula:C7H7Cl2N
- Molecular Weight:176.04
21354-64-3
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Yield:-
Reaction Conditions:
Stage #1: acetic acid-(2,5-dichloro-N-methyl-anilide)with borane-THF in tetrahydrofuran at 20; for 2 h;
Stage #2: with citric acid in tetrahydrofuran;water;
Steps:
16.1
To formic acid (87 eq.) was added dropwise acetic anhydride (19 eq.). After 10 minutes at O0C the mixture was stirred for 1 hour at room temperature. To the mixture was then added dropwise 2,5-dichloroaniline. After 1 hour the solvents were removed under vacuum and the residue was left under high vacuum for 3 hours. The solid obtained was suspended in dry THF at 00C, borane IM in THF (3.0 eq.) was added slowly and the mixture was stirred, for 2 hours at room temperature. The reaction was quenched with a solution 10% of citric acid. THF was evaporated and EtOAc was added. The organic EPO
References:
WO2006/37468,2006,A1 Location in patent:Page/Page column 47-48
6639-55-0
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10224-70-1
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