2-[(4-fluorobenzyl)thio]benzoic acid synthesis
2synthesis methods
- Product Name:2-[(4-fluorobenzyl)thio]benzoic acid
- CAS Number:329063-99-2
- Molecular formula:C14H11FO2S
- Molecular Weight:262.3
Yield:329063-99-2 58%
Reaction Conditions:
Stage #1: Thiosalicylic acidwith sodium hydroxide in methanol at 25; for 0.5 h;
Stage #2: 4-Fluorobenzyl bromide in acetone; for 4 h;Reflux;
Stage #3: with hydrogenchloride in methanol;water;
References:
Porter, Brianne L.;McClure, Beth Anne;Abrams, Eric R.;Engle, James T.;Ziegler, Christopher J.;Rack, Jeffrey J. [Journal of Photochemistry and Photobiology A: Chemistry,2011,vol. 217,# 2-3,p. 341 - 346] Location in patent:experimental part
