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ChemicalBook CAS DataBase List 2 4-DIMETHOXY-5-METHYLPYRIMIDINE 97
5151-34-8

2 4-DIMETHOXY-5-METHYLPYRIMIDINE 97 synthesis

6synthesis methods
-

Yield:5151-34-8 88%

Reaction Conditions:

Stage #1: 5-bromo-2,4-dimethoxypyrimidinewith TurboGrignard in tetrahydrofuran at -20; for 2 h;Inert atmosphere;
Stage #2: with copper(I) cyanide*2 lithium chloride in tetrahydrofuran at -30;
Stage #3: methyl iodide in tetrahydrofuran at 20;Cooling;

References:

Boudet, Nadege;Dubbaka, Srinivas Reddy;Knochel, Paul [Organic Letters,2008,vol. 10,# 9,p. 1715 - 1718] Location in patent:supporting information; experimental part

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