2,4-DICHLOROBENZALDEHYDE OXIME synthesis
- Product Name:2,4-DICHLOROBENZALDEHYDE OXIME
- CAS Number:56843-28-8
- Molecular formula:C7H5Cl2NO
- Molecular Weight:190.03
874-42-0
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56843-28-8
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Yield:56843-28-8 98%
Reaction Conditions:
with hydroxylamine hydrochloride;sodium hydroxide in ethanol;water at 20; for 2 h;Cooling with ice;
Steps:
68
Reference Example-68
Hydroxylamine hydrochloride (748 mg, 10.4 mmol) was added to a solution of 2,4-dichlorobenzaldehyde (1.75 g, 9.49 mmol) in ethanol (10 mL) and water (10 mL), and a sodium hydroxide aqueous solution (37%, 1.8 mL) was added dropwise thereto under ice-cooling, followed by stirring at room temperature for 2 hours.
After the reaction was completed, 2N hydrochloric acid was added to the reaction solution to acidify, and the resultant product was extracted with dichloromethane (20 mL*2.10 mL*1).
The organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure, whereby 2,4-dichlorobenzaldoxime (1.76 g, yield: 98%) was obtained as a white solid. 1H-NMR (400 MHz, CDCl3): δ7.26 (ddd, J=0.6, 2.2 and 8.7 Hz, 1H), 7.42 (d, J=2.2 Hz, 1H), 7.56 (s, 1H), 7.79 (d, J=8.7 Hz, 1H), 8.49 (s, 1H).
References:
US2016/24110,2016,A1 Location in patent:Paragraph 0950; 0951
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391200-38-7
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95-00-1
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95-73-8
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56843-28-8
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