2,4-Dichloro-7-fluoroquinazoline synthesis
- Product Name:2,4-Dichloro-7-fluoroquinazoline
- CAS Number:174566-15-5
- Molecular formula:C8H3Cl2FN2
- Molecular Weight:217.03
76088-98-7
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174566-15-5
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Yield: 78%
Reaction Conditions:
with trichlorophosphate for 72 h;Heating / reflux;
Steps:
100
A suspensionof 7-fluoro-2, 4-dioxo(1H, 3X) quinazoline (Method 98,1. 8 g, 10 mmol) inPOC13 (30 ml) was heated under reflux for 72 hours. The brown coloured solution was concentrated to dryness under vacuum. The residue was treated with ice water (50 ml) and filtered. The residue was washed with ice-cold water (10 ml) and dried to give the desired product(1. 7 g, 78%). 1H NMR(CDC13)5 7.92(m,1 H), 7.95 (d, J = 2.9 Hz, 1 H), 8.42(m,1 H). MS: m/z 219 (M+3), 217(M+1).
References:
ASTRAZENECA AB;ASTRAZENECA UK LIMITED WO2005/49033, 2005, A1 Location in patent:Page/Page column 113
76088-98-7
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$45.00/50mg
174566-15-5
138 suppliers
$25.00/100mg
32315-10-9
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80517-22-2
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174566-15-5
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446-32-2
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174566-15-5
138 suppliers
$25.00/100mg