ChemicalBook CAS DataBase List 2,4-DICHLORO-6-(HYDROXYMETHYL)PHENOL

2,4-DICHLORO-6-(HYDROXYMETHYL)PHENOL synthesis

7synthesis methods

Product Name:2,4-DICHLORO-6-(HYDROXYMETHYL)PHENOL
CAS Number:6641-02-7
Molecular formula:C7H6Cl2O2
Molecular Weight:193.03

50-00-0 Synthesis

50-00-0
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120-83-2 Synthesis

120-83-2
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6641-02-7
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Yield:6641-02-7 76.7%

Reaction Conditions:

with sodium hydroxide in lithium hydroxide monohydrate at 50; for 48 h;

Steps:

1 (1) Synthesis of 2,4-dichloro-6-hydroxymethylphenol

Add 15mL deionized water to a 50mL reaction flask,Then add granular sodium hydroxide (1.3g, 63mmol), stir for 15min until it is completely dissolved, add 2,4-dichlorophenol (5g, 100mmol), add formaldehyde solution (37%-40%, 6mL, 167.6mmol) after dissolution ), stirred at 50°C for 48h, during this process, the solution gradually changed from light yellow to yellow to dark red. After the reaction stopped, the reaction solution was transferred to a beaker, and the pH was adjusted to about 3 with hydrochloric acid while stirring, and a dark red oil appeared. , extracted with CH2Cl2 (3×50mL), then washed with saturated brine, dried over anhydrous sodium sulfate, recrystallized with CH2Cl2 to obtain a white solid (8.3g, 76.7%);

References:

CN114369122,2022,A Location in patent:Paragraph 0029-0031