2-(4-Aminophenyl)-1H-benzimidazol-5-amine synthesis

8synthesis methods

Product Name:2-(4-Aminophenyl)-1H-benzimidazol-5-amine
CAS Number:7621-86-5
Molecular formula:C13H12N4
Molecular Weight:224.26

5-nitro-2-(4-nitrophenyl)-1H-benzimidazole

1772-39-0
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2-(4-Aminophenyl)-1H-benzimidazol-5-amine

7621-86-5
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$9.00/1g

Yield:7621-86-5 96%

Reaction Conditions:

with sodium sulfide;phosphoric acid in water at 100; pH=< 1; for 12 h;

Steps:

1 In the compound having a structure represented by the formula (I), R is a structure represented by the formula (1), and 2-(4-nitrophenyl)-5-nitrobenzimidazole is obtained.

At room temperature,To a 100 mL ml single-necked flask was added 2-(4-nitrophenyl)-5-nitrobenzimidazole (2.84 g, 0.01 mol) and 50 mL of water,Adding phosphoric acid,Adjust the pH below 1.Add sodium sulfide solid (3.9 g, 0.05 mol),Warming up to 100 ° C,Continuous reaction for 12 h. After being cooled to room temperature, it was filtered, and the filtrate was neutralized to a pH of 7 by adding a sodium carbonate aqueous solution having a concentration of 25% by weight, and the product was precipitated from the reaction system, filtered, washed with water several times, and dried to obtain 2.15 g of the product 2-(4). -aminobenzene)-5-aminobenzimidazole (yield 96%, purity (HPLC) >99.9%),

References:

CN108558770,2018,A Location in patent:Paragraph 0079; 0080; 0081

37632-91-0 Synthesis