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ChemicalBook CAS DataBase List 2,4,6-TRIHYDROXY PHENYL BENZYL KETONE
727-71-9

2,4,6-TRIHYDROXY PHENYL BENZYL KETONE synthesis

7synthesis methods
Preparation by reaction of phenylacetonitrile with phloroglucinol (Hoesch reaction),
? in the presence of boron trifluoride etherate (50%).
-

Yield:727-71-9 72.5%

Reaction Conditions:

Stage #1: 3,5-dihydroxyphenol;phenylacetonitrilewith hydrogenchloride;zinc(II) chloride in diethyl ether at 0 - 20;
Stage #2: with water in methanol; for 5 h;Reflux;

References:

Ng, Lean-Teik;Ko, Horng-Huey;Lu, Tzy-Ming [Bioorganic and Medicinal Chemistry,2009,vol. 17,# 13,p. 4360 - 4366] Location in patent:experimental part

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