ChemicalBook CAS DataBase List 2,3-dimethyl-2H-indazol-6-amine hydrochloride

2,3-dimethyl-2H-indazol-6-amine hydrochloride synthesis

4synthesis methods

Product Name:2,3-dimethyl-2H-indazol-6-amine hydrochloride
CAS Number:635702-60-2
Molecular formula:C9H12ClN3
Molecular Weight:197.6647

444731-73-1 Synthesis

444731-73-1
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2,3-dimethyl-2H-indazol-6-amine hydrochloride

635702-60-2
243 suppliers
$10.00/1g

Yield:635702-60-2 96%

Reaction Conditions:

with hydrogenchloride;tin(ll) chloride in diethylene glycol dimethyl ether;water at 0; for 0.583333 h;

Steps:

2.1 Intermediate Example 2; Preparation of 2,3-dimethyl-6-amino-2H-indazole; Procedure 1

To a stirred solution of 2, [3-DIMETHYL-6-NITRO-2H-INDAZOLE] (1.13 g) in 2- methoxyethyl ether (12 [ML),] at [0] [C,] was added a solution of 4.48 g of tin [(LL)] chloride in 8.9 ml of concentrated HCI dropwise over 5 min. After the addition was complete, the ice bath was removed and the solution was allowed to stir for an additional 30 min. Approximately 40 ml of diethyl ether was added to reaction, resulting in precipitate formation. The resulting precipitate was isolated by filtration and washed with diethyl ether, and afforded a yellow solid (1.1 g, 95 [%),] the HCI salt 2,3- [DIMETHYL-2H-INDAZOL-6-AMINE.'H] NMR (300 MHz, [DMSO-D6)] 8 7. [77] (d, [J =] 8.9 [HZ,] [1 H),] 7.18 (s, [1 H),] 7.88 (m, [1 H),] 4.04 (s, 3H), 2.61 (s, 3H). MS [(ES+,] m/z) 162 (M+H).

References:

WO2003/106416,2003,A2 Location in patent:Page 42-43

6494-19-5 Synthesis