天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 2,3-DIHYDRO-2,2-DIMETHYLINDEN-1-ONE
10489-28-8

2,3-DIHYDRO-2,2-DIMETHYLINDEN-1-ONE synthesis

13synthesis methods
-

Yield:17496-14-9 450 mg ，10489-28-8 900 mg

Reaction Conditions:

with n-butyllithium in tetrahydrofuran at 0; for 1 h;

Steps:

T-27 Example T-27: Alkylation alpha to a ketone

To a solution of 2,3-dihydro-1H-inden-1-one (2 g, 15.13 mmol) in THF (50 mL) was added iodomethane (2.15 g, 15.13 mmol) and butyllithium (0.97 g, 15.13 mmol). The reaction mixture was cooled to 0 °C and stirred at that temperature for 1 h. Na2S2O3 (20 mL) was added to the reaction vessel and was extracted with DCM (3 x 15 ml). The layers were separated and the organic phase was washed with saturated aqueous NaCl (2 x 15 mL). The combined organics were dried over anhydrous Na2SO4, filtered and concentrated in vacuo. After concentration, the residue was purified by silica column chromatography with a gradient elution of hexane to hexane (90%) and EtOAc (10%) to give the product 2-methyl-2,3-dihydro-1H-inden-1-one (450 mg, 3.08 mmol) and 2,2-dimethyl-2,3- dihydro-1H-inden-1-one (900 mg, 5.62 mmol) as a yellow oil.

References:

WO2018/26371,2018,A1 Location in patent:Paragraph 0220

2,3-DIHYDRO-2,2-DIMETHYLINDEN-1-ONE Related Search: