ChemicalBook CAS DataBase List 2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDINE

2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDINE synthesis

5synthesis methods

Product Name:2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDINE
CAS Number:496-13-9
Molecular formula:C7H8N2
Molecular Weight:120.15

Ethyl1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxylate

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Yield: 72%

Reaction Conditions:

with barium(II) hydroxide in water at 120;

Steps:

13.7 Step 7. 2,3-Dihydro- 1H-pyrrolo[3,4-clpyridine.
[0222] Step 7. 2,3-Dihydro- 1H-pyrrolo[3,4-clpyridine. A mixture of ethyl 1H,2H,3H- pyrrolo[3,4-c]pyridine-2(3H)-carboxylate (400 mg, 2.4 mmol, 1.00 equiv) and barium hydroxide (0.8 g) in water (100 mL) was stirred overnight at 120 °C. The reaction mixture was cooled to rt and the solid material was collected by filtration. The residue was stirred in hot ethyl acetate (150 mL) and then filtered to remove solid material. The filtrate was concentrated under vacuum to give 0.18 g (72%) of 2,3-dihydro- 1H-pyrrolo[3,4-c]pyridine as a light yellow oil. ‘H NMR (300 MHz, CDC13) ? 8.51 (s, 1H), 8.41-8.45 (t, J = 4.8 Hz, 1H), 7.13-7.20 (m, 1H), 4.25 (s, 2H), 4.22 (s, 2H).

References:

GENENTECH, INC.;FORMA TM, LLC;BAIR, Kenneth, W.;BAUMEISTER, Timm, R.;GOSSELIN, Francis;ZAK, Mark;ZHENG, Xiaozhang WO2013/130935, 2013, A1 Location in patent:Paragraph 0222

10070-92-5 Synthesis