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ChemicalBook CAS DataBase List 2,3-DIHYDRO-1H-ISOINDOLE-1-CARBOXYLIC ACID
66938-02-1

2,3-DIHYDRO-1H-ISOINDOLE-1-CARBOXYLIC ACID synthesis

2synthesis methods
221352-46-1 Synthesis
1,3-DIHYDRO-ISOINDOLE-1,2-DICARBOXYLIC ACID 2-TERT-BUTYL ESTER

221352-46-1
95 suppliers
$42.00/100mg

96016-96-5 Synthesis
2,3-DIHYDRO-1H-ISOINDOLE-1-CARBOXYLIC ACID HYDROCHLORIDE

96016-96-5
26 suppliers
$50.00/100mg

-

Yield:96016-96-5 100%

Reaction Conditions:

in ethyl acetate;

Steps:

1.A Step A

Step A 1,3-Dihydro-2H-isoindole-1-carboxylic acid N-BOC-1,3-dihydro-2H-isoindole-1-carboxylic acid (Neosystem, 0.5 g, 1.9 mmol) was dissolved in EtOAc and HCl gas was bubbled through the solution for a few seconds. The reaction mixture was stirred at rt for 10 minutes and then concentrated in vacuo to afford 1,3-dihydro-2H-isoindole-1-carboxylic acid, hydrochloride (0.31 gm, 100%) which was used without further purification in the subsequent reaction.

References:

US2002/193399,2002,A1

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