2,3-DIHYDRO-1-BENZOFURAN-5-YLMETHANOL synthesis
- Product Name:2,3-DIHYDRO-1-BENZOFURAN-5-YLMETHANOL
- CAS Number:103262-35-7
- Molecular formula:C9H10O2
- Molecular Weight:150.17
![2,3-Dihydrobenzo[b]furan-5-carboxylic acid](/CAS/GIF/76429-73-7.gif)
76429-73-7
131 suppliers
$13.00/250mg
103262-35-7
70 suppliers
$45.00/50mg
Yield: 100%
Reaction Conditions:
with hydrogenchloride in tetrahydrofuran;methanol
Steps:
R.13.1 (2,3-dihydrobenzo[b]furan-5-yl)methanol
Reference Example 13-1 (2,3-dihydrobenzo[b]furan-5-yl)methanol To a solution of 2,3-dihydrobenzo[b]furan-5-carboxylic acid (1.64 g, 10 mmol) in tetrahydrofuran (10 mL) was added under ice-cooling lithium aluminum hydride (949 mg, 25 mmol) and the mixture was stirred at 60°C for 1 h. The reaction mixture was stirred under ice-cooling and methanol and 1N hydrochloric acid were added. The precipitate was filtered off and the mother liquor was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give an almost pure title compound (1.5 g, 100%).
References:
Takeda Chemical Industries, Ltd. EP1223170, 2002, A1
![2,3-Dihydrobenzo[b]furan-5-carbaldehyde](/CAS/GIF/55745-70-5.gif)
55745-70-5
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$6.00/1g
103262-35-7
70 suppliers
$45.00/50mg
496-16-2
374 suppliers
$7.00/5g
103262-35-7
70 suppliers
$45.00/50mg