2,2-DIMETHYL-3-OXO-3-PHENYLPROPANAL synthesis

5synthesis methods

Product Name:2,2-DIMETHYL-3-OXO-3-PHENYLPROPANAL
CAS Number:1750-74-9
Molecular formula:C11H12O2
Molecular Weight:176.21

5440-69-7
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2403-57-8
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1750-74-9
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611-70-1 Synthesis

611-70-1
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Yield:611-70-1 60% ，1750-74-9 15%

Reaction Conditions:

Stage #1: N-isopropylbenzamidewith 2-fluoropyridine;trifluoromethylsulfonic anhydride in dichloromethane at 0; for 0.333333 h;Inert atmosphere;Schlenk technique;Stork Enamine Alkylation;
Stage #2: 1-(2-methylprop-1-en-1-yl)pyrrolidine in dichloromethane at 0 - 20; for 3 h;Inert atmosphere;Schlenk technique;Stork Enamine Alkylation;
Stage #3: with water in dichloromethane at 20;Inert atmosphere;Schlenk technique;Stork Enamine Alkylation;Reagent/catalyst;

References:

Liu, Yong-Peng;Wang, Shu-Ren;Chen, Ting-Ting;Yu, Cun-Cun;Wang, Ai-E;Huang, Pei-Qiang [Advanced Synthesis and Catalysis,2019,vol. 361,# 5,p. 971 - 975] Location in patent:supporting information