ChemicalBook CAS DataBase List 2-(2-Bromophenyl)-2-propanol

2-(2-Bromophenyl)-2-propanol synthesis

15synthesis methods

Product Name:2-(2-Bromophenyl)-2-propanol
CAS Number:7073-69-0
Molecular formula:C9H11BrO
Molecular Weight:215.09

610-94-6 Synthesis

610-94-6
305 suppliers
$13.00/25g

75-16-1
269 suppliers
$12.00/10ml

7073-69-0
84 suppliers
$22.00/250mg

Yield: 98.2%

Reaction Conditions:

Stage #1:2-bromobenzoic acid methyl ester;methylmagnesium bromide in tetrahydrofuran at 20;Cooling with ice;
Stage #2: with hydrogenchloride in water; pH=5 - 6

Steps:

2 Example 2: Preparation of compound II (taking methyl 2-bromobenzoate as an example)
Methyl 2-bromobenzoate (226g, 1.05mol) was dissolved in THF (1.6L), and 3MCH3MgBr (1.05L, 3.15mol) was added dropwise under ice-water bath conditions. After the addition was completed, a white syrupy liquid was formed. Slowly rise to room temperature and stir until the reaction is complete. Under ice-water bath conditions, use HCl (4.5L, 0.5 M, 2.25mol) to quench the reaction slowly. After the addition is complete, continue to stir for 0.5h, then add 2N HCl (0.5 L, 1.00mol) to make the pH value 5-6 . Add MTBE (1L), separate the organic phase, extract the aqueous phase with MTBE (2×0.5L), combine the organic phases, wash with sodium bicarbonate solution (2×0.3L), dry with anhydrous sodium sulfate, filter, and concentrate , 222 g (98.2% yield) of compound II was obtained as a solid.

References:

CN112430177, 2021, A Location in patent:Paragraph 0067; 0068

917-64-6 Synthesis