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ChemicalBook CAS DataBase List 2',2,2-TRIMETHYLPROPIOPHENONE
2041-37-4

2',2,2-TRIMETHYLPROPIOPHENONE synthesis

10synthesis methods
-

Yield:2041-37-4 98%

Reaction Conditions:

Stage #1: 2,2-dimethylpropiophenone;trimethylaluminumwith iron(III)-acetylacetonate;4-(bis(2-(diphenylphosphanyl)phenyl)phosphanyl)-N,N-dimethylaniline in tetrahydrofuran;toluene at 20;Inert atmosphere;Schlenk technique;
Stage #2: with 2,3-dichlorobutane in tetrahydrofuran;toluene at 70; for 16 h;Mechanism;Inert atmosphere;Schlenk technique;Sealed tube;

References:

Shang, Rui;Ilies, Laurean;Nakamura, Eiichi [Journal of the American Chemical Society,2016,vol. 138,# 32,p. 10132 - 10135] Location in patent:supporting information