2(1H)-Quinolinone,8-bromo-1-methyl-(9CI) synthesis
- Product Name:2(1H)-Quinolinone,8-bromo-1-methyl-(9CI)
- CAS Number:67805-53-2
- Molecular formula:C10H8BrNO
- Molecular Weight:238.08
67805-67-8
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Yield:-
Reaction Conditions:
with sodium hydroxide;dimethyl sulfate in methanol;water;
Steps:
2 (Procedure B)
EXAMPLE 2 (Procedure B) One gram of sodium hydroxide was dissolved in 15 ml. of methanol, and 4.5 g. of 8-bromocarbostyril was added to the solution at room temperature. Thereafter, 2.6 g. of dimethyl sulfate was added dropwise thereto. The reaction mixture was boiled for 3 hours, cooled to room temperature and poured into 50 ml. of water. The precipitated crystals were filtered, dried and recrystallized from ethanol to obtain 3.9 g. of 8-bromo-1-methylcarbostyril (m.p. 106°-107° C.).
References:
US4349554,1982,A
16567-18-3
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