ChemicalBook CAS DataBase List (1S,2S)-Boc-1,2-diaminocyclohexane

(1S,2S)-Boc-1,2-diaminocyclohexane synthesis

8synthesis methods

Product Name:(1S,2S)-Boc-1,2-diaminocyclohexane
CAS Number:180683-64-1
Molecular formula:C11H22N2O2
Molecular Weight:214.3

N-Boc-1S,2S-Cyclohexanediamine can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly in laboratory research and development. It was prepared from (1S,2S)-(+)-1,2-Diaminocyclohexane and Di-tert-butyl dicarbonate by stirring in DCM for 5 h at room temperature.

21436-03-3 Synthesis

21436-03-3
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180683-64-1
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$21.00/100mg

Yield:-

Steps:

R.39 (+-)-trans-N-tert-Butoxycarbonyl-1,2-cyclohexanediamine:
[Referential Example 39] (+-)-trans-N-tert-Butoxycarbonyl-1,2-cyclohexanediamine: The title compound was obtained from (+-)-trans-1,2-cyclohexanediamine in a similar manner to Referential Example 34. mp 79-81°C. ¹H-NMR (CDCl₃) δ: 1.05-1.34(4H,m), 1.45(9H,s), 1.68-1.75(2H,m), 1.92-2.02(2H,m), 2.32(1H,dt,J=10.3,3.9Hz), 3.08-3.20(1H,m), 4.50(1H,br.s). MS (FAB) m/z: 215(M+H)⁺.

References:

DAIICHI PHARMACEUTICAL CO., LTD. EP1270557, 2003, A1

24424-99-5 Synthesis