ChemicalBook CAS DataBase List 1H-Benzimidazole-6-carboxaldehyde, 1-methyl- (9CI)

1H-Benzimidazole-6-carboxaldehyde, 1-methyl- (9CI) synthesis

12synthesis methods

Product Name:1H-Benzimidazole-6-carboxaldehyde, 1-methyl- (9CI)
CAS Number:181867-19-6
Molecular formula:C9H8N2O
Molecular Weight:160.17

64-18-6 Synthesis

64-18-6
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1H-Benzimidazole-6-carboxaldehyde, 1-methyl- (9CI)

181867-19-6
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Yield:181867-19-6 95%

Reaction Conditions:

Stage #1: formic acid;4-amino-3-(methylamino)benzonitrile at 100; for 2 h;
Stage #2: with water;Raney nikel at 100; for 1 h;

Steps:

1.d

(d) 1-Methyl-lH-benzimidazole-6-carbaldehyde; A mixture of 4-amino-3- (methylamino) benzonitrile (0.40 g, 2.72 mmol) in HCO2H (9 mL) was heated to 100 °C for 2 h. The mixture of crude benzimidazole was then cooled, Raney nickel (0.4 g) and H2O (2 mL) were added, and the mixture was heated again to 100°C for 1 h. The hot mixture was then filtered through Celite, rinsed with MeOH and concentrated under reduced pressure. Water (1 mL) was added to the residue, which was then treated carefully with sat. aq. NaHCO3. The solid which precipitated was filtered, rinsed with H20 and dried to afford 1-methyl-lH-benzimidazole-6-carbaldehyde (0.412 g, 95%) as a tan solid, which was used directly in the next reaction. lH NMR (CDCl3) : No. 10.12 (s, 1H), 8.05 (s, 1H), 8.00 (d, J= 0. 8 Hz, 1H), 7.92 (d, J= 8.0 Hz, 1H), 7.84 (dd, J= 1. 2, 8. 0 Hz, 1H), 3.94 (s, 3H).

References:

WO2005/82901,2005,A1 Location in patent:Page/Page column 40