ChemicalBook CAS DataBase List 1H,1H-PENTADECAFLUORO-1-OCTANOL

1H,1H-PENTADECAFLUORO-1-OCTANOL synthesis

6synthesis methods

Product Name:1H,1H-PENTADECAFLUORO-1-OCTANOL
CAS Number:307-30-2
Molecular formula:C8H3F15O
Molecular Weight:400.08

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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307-30-2
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Yield: 95%

Reaction Conditions:

with RuCl2(DPPEA)(±DAIPEN);hydrogen;sodium methylate in isopropyl alcohol;benzene at 100; under 750.075 - 45004.5 Torr; for 40 h;Autoclave;

Steps:

3
To the autoclave were charged 228 g of isopropyl pentafluorooctanoate and 114 g of isopropyl alcohol and 19 g of benzene, and then 35.8(RuCl2 (DPPEA) (± DAIPEN)) and 270 mg of sodium methoxide were sealed and charged with N2 to a pressure of 0.1 MPa for three times, and then replaced by H2 to a pressure of 0.2 MPa for three times. After the replacement, the temperature was raised to 100C, Charge H2 pressure to 6.0MPa,After completion of the reaction for 40 hours, the reaction mixture was cooled, the cooled reaction solution was transferred to a distillation apparatus, and the temperature was adjusted to control the reflux ratio of 12:1, collecting the temperature of 80 ~ 88 fractions (distillate is solvent alcohol and benzene), after the end of the cooling, the residual solution into the equal volume of distilled water, stir, with the mass fraction of about 1% hydrochloric acid to adjust the pH value And the organic phase of the lower layer was dried with anhydrous sodium sulfate. The filtrate was distilled and the resulting fraction was weighed 190g, that is, pentafluoropentanol, the purity of the gas was 99.4%, the yield was 95 %.

References:

Wuhan Institute of Technology;Wuhan Kaisen Chemical Co., Ltd.;Xi, Qiang;Hu, Yang;Feng, Weiwei;Shu, Chang;Yang, Haitao;Zeng, Tianyu;Zhang, Zhipeng CN104829432, 2017, B Location in patent:Paragraph 0030