ChemicalBook CAS DataBase List 6-Benzothiazolecarboxylicacid,ethylester(6CI,8CI,9CI)

6-Benzothiazolecarboxylicacid,ethylester(6CI,8CI,9CI) synthesis

6synthesis methods

Product Name:6-Benzothiazolecarboxylicacid,ethylester(6CI,8CI,9CI)
CAS Number:19989-64-1
Molecular formula:C10H9NO2S
Molecular Weight:207.25

50850-93-6 Synthesis

Ethyl 2-amino-1,3-benzothiazole-6-carboxylate

50850-93-6
174 suppliers
$9.00/1g

6-Benzothiazolecarboxylicacid,ethylester(6CI,8CI,9CI)

19989-64-1
60 suppliers
$108.75/1g

Yield:19989-64-1 62%

Reaction Conditions:

with silver(I) nitrite in 1,2-dichloro-ethane at 100; for 36 h;Sealed tube;

Steps:

9 Example 9

It was added in a closed reaction vessel 0.3mmol2-amino-benzothiazole-6-ester, 0.6mmol silver nitrite, 4 ml of 1,2-dichloroethane,the reaction mixture was stirred at 100 for 36 hours. After the reactionwas stopped, cooled to room temperature, the reaction mixture was added 10mLdiluted with dichloromethane, filtration and stripped of solvent under reducedpressure, the residue was purified by column chromatography, eluent V(petroleum ether) / V (ethyl ester) = 6/1, to give 6-ester-benzothiazole, yield62%

References:

CN105367442,2016,A Location in patent:Paragraph 0021

99073-88-8 Synthesis