3-CYANO-4-HYDROXYPYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER synthesis
- Product Name:3-CYANO-4-HYDROXYPYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS Number:197143-33-2
- Molecular formula:C10H16N2O3
- Molecular Weight:212.25
175463-32-8
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Yield:197143-33-2 92%
Reaction Conditions:
with sodium tetrahydroborate in ethanol at 0 - 20; for 3 h;
Steps:
Tert-Butyl 3-cyano-4-hydroxypyrrolidine-1-carboxylate
Anhydrous ethanol (50 ml) was added to a three-necked bottle (100 ml), and the compound tert-butyl 3-cyano-4-carbonylpyrrolidine-1-carboxylate (3.00 g, 14.3 mmol) was added at 0 Sodium borohydride (1.08 g, 28.6 mmol) was slowly added at 0 degree, and the reaction system was stirred at 20 degree for 3 hours. 10 ml of water was added to the reaction system, and most of the solvent was concentrated and dried. More 50 ml of water was added, extracted three times with ethyl acetate, and the organic phase was concentrated to dryness to obtain a white solid (2.79 g, yield 92%).
References:
CN111039946,2020,A Location in patent:Paragraph 0188-0192
44981-94-4
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