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2-(4-METHOXY-BENZENESULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID
2-(4-METHOXY-BENZENESULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID synthesis
1synthesis methods
- Product Name:2-(4-METHOXY-BENZENESULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID
- CAS Number:191326-98-4
- Molecular formula:C17H17NO5S
- Molecular Weight:347.39
Yield:-
Reaction Conditions:
with triethylamine in Dichlorofluoromethane;
Steps:
21 Ciompound 21 2-[(4-Methoxyphenyl)sulfonyl]-N-(3-thioxo-3H-1,2,4-dithiazol-5-yl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide
1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid hydrochloride is reacted with 4-methoxybenzenesulfonyl chloride in dichloromethane in the presence of triethylamine, to give 2-[(4-methoxyphenyl)sulfonyl]-1,2,3,4-tetrahydro-3-isoquinoline carboxylic acid.
References:
EP1422224,2004,A1 Location in patent:Page 37