(S)-2-(tert-Butoxycarbonylamino)-4-(dimethylamino)butanoic acid synthesis
- Product Name:(S)-2-(tert-Butoxycarbonylamino)-4-(dimethylamino)butanoic acid
- CAS Number:181518-87-6
- Molecular formula:C11H22N2O4
- Molecular Weight:246.3
25691-37-6
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181518-87-6
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Yield:-
Reaction Conditions:
with formaldehyd;hydrogen;acetic acid;palladium(II) hydroxide in methanol at 20;
Steps:
To a suspension Of Pd(OH)2, (20%, 100 mg), aqueous formaldehyde (37% wt, 4 ml), acetic acid, (0,5 mL) in methanol (15 mL) was added (S)-4-amino-2~(tert- butoxycarbonylamino)butanoic acid (1 g, 4.48 mmol). The reaction was purged several times with hydrogen and was stirred overnight with an hydrogen balloon room temp. The reaction mixture was filtered through a pad of diatomaceous earth (CELITE), and the volatile component was removed in vacuo. The resulting crude material was used as is for the next step. LC/MS: Anal Calcd. for C j 1H22N2O4: 246; found: 247 (M+H)+.
References:
WO2010/138488,2010,A1 Location in patent:Page/Page column 142
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25691-37-6
192 suppliers
$11.00/250mg
181518-87-6
14 suppliers
$312.00/250mg
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181518-87-6
14 suppliers
$312.00/250mg
76969-87-4
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181518-87-6
14 suppliers
$312.00/250mg