3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXALDEHYDE synthesis
- Product Name:3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXALDEHYDE
- CAS Number:175277-50-6
- Molecular formula:C7H3ClF3NO
- Molecular Weight:209.55
![[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methanol](/CAS/GIF/1033463-31-8.gif)
1033463-31-8
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175277-50-6
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Yield: 57%
Reaction Conditions:
with Dess-Martin periodane in dichloromethane at 0 - 23; for 3 h;
Steps:
3 Step 3: (3-chloro-5-(trifluoromethyl)pyridin-2-yl)methanol
DMP (60.2g, 142.lommol) was added portion wise to a stirred solution of(3-chloro-5-(trifluoromethyl)- pyridin-2-yl)methanol (15g, 71.Ommol) in DCM (lOOmL) at 0°C and stirred for 3 h at RT. The RM was filtered through a celite bed and washed with DCM (3x1 OOmL).The clear filtrate was washed with aq. NaHCO3 (200mL), water (200mL), brine(250mL), dried over anhydr. Na2SO4, filtered, concentrated under reduced pressure to get the crude product. The crude was purified by CC (0-5% EtOAc in PE) to give (3-chloro-5-(trifluoromethyl)pyridin-2-yl)methanol (8g, 57%) as liquid..
References:
GRüNENTHAL GMBH;SCHUNK, Stefan;REICH, Melanie;JAKOB, Florian;DAMANN, Nils;HAURAND, Michael;KLESS, Achim;ROGERS, Marc;SUTTON, Kathy WO2015/158427, 2015, A1 Location in patent:Page/Page column 87
69045-84-7
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175277-50-6
88 suppliers
$46.00/100mg