(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine synthesis
- Product Name:(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine
- CAS Number:171338-33-3
- Molecular formula:C20H19F6NO2
- Molecular Weight:419.36
785-56-8
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171338-33-3
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Yield:-
Steps:
Multi-step reaction with 3 steps
1: 1.) L-Selectride / 1.) THF, -78 deg C, 45 min, 2.) THF, -78 deg C, 30 min
2: 69 percent / tetrahydrofuran; toluene / 18 h / Heating
3: 75 percent / H2 / 10percent Pd/C / ethyl acetate; propan-2-ol / 48 h
References:
Hale, Jeffrey J.;Mills, Sander G.;MacCoss, Malcolm;Finke, Paul E.;Cascieri, Margaret A.;Sadowski, Sharon;Ber, Elzbieta;Chicchi, Gary G.;Kurtz, Marc;Metzger, Joseph;Eiermann, George;Tsou, Nancy N.;Tattersall, F. David;Rupniak, Nadia M. J.;Williams, Angela R.;Rycroft, Wayne;Hargreaves, Richard;MacIntyre, D. Euan [Journal of Medicinal Chemistry,1998,vol. 41,# 23,p. 4607 - 4614]
![Morpholine, 2-[[1-[3,5-bis(trifluoromethyl)phenyl]ethenyl]oxy]-3-phenyl-4-(phenylmethyl)-, (2R,3S)-](/CAS/20210305/GIF/170729-73-4.gif)
100-58-3
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![(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE](/CAS/GIF/287930-75-0.gif)
287930-75-0
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171338-33-3
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159706-35-1
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171338-33-3
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170729-72-3
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171338-33-3
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