天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 17-BETA-ESTRADIOL 3-METHYL ETHER
1035-77-4

17-BETA-ESTRADIOL 3-METHYL ETHER synthesis

11synthesis methods
-

Yield:1035-77-4 97%

Reaction Conditions:

with sodium carbonate in methanol; for 64 h;Reflux;Inert atmosphere;

Steps:

2.1.1. Starting from 17β-estradiol

A mixture of 17β-estradiol (2.86 g, 10.5 mmol), sodium carbonate (11.1 g, 105 mmol) and iodomethane (17 mL, 38.8 g, 273 mmol) in methanol (50 mL) was heated under reflux with stirring. After 16 h, iodomethane (1 mL, 2.28 g, 16 mmol) was added and the mixture was heated for 48 h. This suspension was then filtered and the inorganic salts were washed with methanol (150 mL). The methanolicsolution was distilled under vacuum to give a white solid which was redissolved in boiling methanol (50 mL). Water (250 mL) was slowly added to the boiling solution of methanol with vigorous stirring, leading to the precipitation of a white solid. After 2 h stirring at room temperature, the precipitate was recovered by filtration, washed with water (250 mL) and dried under vacuum at 90 °C to give 2.92 g (yield: 97%) of 17β-estradiol-3-methyl ether 1.

References:

Balssa, Frédéric;Fischer, Michael;Bonnaire, Yves [Steroids,2014,vol. 86,p. 1 - 4]

17-BETA-ESTRADIOL 3-METHYL ETHER Related Search: