ChemicalBook CAS DataBase List N-ALFA-FMOC-4-(PHOSPHONODIFLUOROMETHYL)-L-PHENYLALANINE

N-ALFA-FMOC-4-(PHOSPHONODIFLUOROMETHYL)-L-PHENYLALANINE synthesis

8synthesis methods

Product Name:N-ALFA-FMOC-4-(PHOSPHONODIFLUOROMETHYL)-L-PHENYLALANINE
CAS Number:160751-44-0
Molecular formula:C25H22F2NO7P
Molecular Weight:517.42

6232-88-8 Synthesis

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N-ALFA-FMOC-4-(PHOSPHONODIFLUOROMETHYL)-L-PHENYLALANINE

160751-44-0
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Yield:-

Steps:

Multi-step reaction with 7 steps
1: phosphorus tribromide / 3 h / Heating
2: 1.9 g / toluene / 0.67 h / 0 °C
3: 52 percent / (diethylamido)sulfur trifluoride / Ambient temperature
4: 78 percent / hexamethylphosphoramide, LiN(TMS)2 / tetrahydrofuran / 0.75 h / -78 °C
5: 100 percent / H₂ / PdCl₂ / ethanol; tetrahydrofuran; methanol / 20 h / 2585.7 Torr
6: 1.29 g / NaHCO₃ / H₂O; dioxane / 3 h / Ambient temperature
7: 1.19 g / bis(trimethylsilyl)trifluoroacetamide, iodotrimethylsilane / CH₂Cl₂ / -20 - 20 °C

References:

Solas, Dennis;Hale, Ron L.;Patel, Dinesh V. [Journal of Organic Chemistry,1996,vol. 61,# 4,p. 1537 - 1539]