L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE synthesis
- Product Name:L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE
- CAS Number:1421-65-4
- Molecular formula:C10H14ClNO4
- Molecular Weight:247.68
59-92-7
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$14.00/5g
1421-65-4
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$5.00/250mg
Yield:-
Reaction Conditions:
with thionyl chloride in methanol;toluene
Steps:
131 3-(3,4-Dihydroxyphenyl)-L-alanine methyl ester hydrochloride
3-(3,4-Dihydroxyphenyl)-L-alanine methyl ester hydrochloride A solution of 1.97 g (10 mmol) of L-DOPA 15 in 100 ml of MeOH at 0° C. was added 6.57 ml (90 mmol) of thionyl chloride via addition funnel. The mixture was stirred overnight while the temperature was slowly warmed to room temperature. The solvent was evaporated and the thick oil was treated with toluene (3*15 ml) and evaporated. The yield of white solid was 3.26 g (100%); NMR (DMSQ-d6) δ 2.90 (m, 2H), 3.38 (bs, 2H), 3.61 (s, 3H), 4.08 (m, 1H), 6.40 (d, 1H, J=7 Hz), 6.59 (s, 1H), 6.65(d, 2H, J=7 Hz), 8.59 (bs, 1H), 8.90 (d, 1H, J=10 Hz). MS: 212 m/z (M+H)+.
References:
Cephalon, Inc. US5952328, 1999, A
67-56-1
751 suppliers
$7.29/5ml-f
59-92-7
677 suppliers
$14.00/5g
1421-65-4
116 suppliers
$5.00/250mg
59-92-7
677 suppliers
$14.00/5g
75-36-5
578 suppliers
$17.92/100G
1421-65-4
116 suppliers
$5.00/250mg