Yield:13694-13-8 78%

Reaction Conditions:

in ethanol; for 5 h;Reflux;

Steps:

4.1.53 General procedure VI - synthesis of 7-methyl-2-arylo-imidazo[1,2-a]pyrimidines (60a-60j)

General procedure: To a solution of 2-amino-4-methylpyrimidine (59, 1 eq.) in absolute EtOH (100 mL) the appropriate phenacyl bromide (1 eq.) was added and the whole was heated at reflux for 5 h. After cooling to RT water (100 mL) and CHCl₃ (200 mL) were added and the organic phase was separated. Water phase was neutralized to pH 7 with aqueous NaOH, adjusted to pH 9 with aq. NaHCO₃ extracted with chloroform (3×40 mL) and dried with Na₂SO₄. The solvent was evaporated and the residue was recrystallized from AcOEt/EtOH (2:1, v/v). The precipitate was filtered and washed with AcOEt, affording pure product.

References:

Moszczyński-P?tkowski, Rafa?;Majer, Jakub;Borkowska, Ma?gorzata;Bojarski, ?ukasz;Janowska, Sylwia;Mat?oka, Miko?aj;Stefaniak, Filip;Smuga, Damian;Bazyd?o, Katarzyna;Dubiel, Krzysztof;Wieczorek, Maciej [European Journal of Medicinal Chemistry,2018,vol. 155,p. 96 - 116]