Yield: 96%

Reaction Conditions:

with hydrogenchloride;water for 16 h;Reflux;

Steps:

4.1
Step 11-Benzyl-4-hydroxy-piperidine-4-carboxylic acid, hydrochloride A mixture of 8 g (32 mmol) 1-benzyl-4-cyano-4-hydroxypiperidine hydrochloride and 15.8 mL HCl (37%) was heated to reflux for 16 h. The solution was cooled to room temperature and the white precipitate was filtered off and washed with iso-propanol. The filtrate was evaporated to yield 9.71 g (96%) of the title compound as white waxy solid which was used without further purification. MS (m/e): 234.4[(MH)-].

References:

Ackermann, Jean;Conte, Aurelia;Hunziker, Daniel;Neidhart, Werner;Nettekoven, Matthias;Wertheimer, Stanley US2011/28515, 2011, A1 Location in patent:Page/Page column 17