ChemicalBook CAS DataBase List 5-N-Boc-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic acid

5-N-Boc-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic acid synthesis

7synthesis methods

Product Name:5-N-Boc-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic acid
CAS Number:1209492-73-8
Molecular formula:C12H17N3O4
Molecular Weight:267.28

Pyrazolo[1,5-a]pyrazine-2,5(4H)-dicarboxylic acid, 6,7-dihydro-, 5-(1,1-dimethylethyl) 2-methyl ester

1209492-72-7
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5-N-Boc-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic acid

1209492-73-8
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$275.00/100mg

Yield:1209492-73-8 100%

Reaction Conditions:

with water;sodium hydroxide in tetrahydrofuran;methanol at 20; for 1.5 h;

Steps:

2-1.6
Step 6 To a solution of Compound 17 (2.10 g, 7.47 mmol) in tetrahydrofuran:methanol (1:1, 30 mL), aqueous 2 mol/L sodium hydroxide solution (7.47 mL, 14.9 mmol) was added. The solution was then stirred at room temperature for one and a half hours. Water was added to the reaction solution, acidified, and then extracted with ethyl acetate. The extract was dried with anhydrous magnesium sulfate, and then concentrated in vacuo to yield Compound 18 (2.02 g, 100%) . LC/MS (Method D): 1.21 min, [M+H]⁺ = 268 ¹H-NMR (DMSO-d₆) δ: 12.58 (1H, brs), 6.58 (1H, s), 4.61 (2H, s), 4.16 (2H, t, J = 5.5 Hz), 3.82 (2H, t, J = 5.5 Hz), 1.44 (9H, s).

References:

Shionogi&Co., Ltd. EP2327704, 2011, A1 Location in patent:Page/Page column 53

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3112-31-0 Synthesis