Yield:-

Reaction Conditions:

with methanol;water;sodium hydroxide at 20;Reagent/catalyst;

Steps:

1-4 Hydrolysis process:

place 50.00 g of ethyl desmethyl thiazide, 150 ml of tap water and 50 ml of methanol in a 500 ml three-necked flask, add 27.00 g of sodium hydroxide to the system at room temperature, and stir overnight to obtain compound 1.

References:

CN112645898,2021,A Location in patent:Paragraph 0038; 0039; 0042; 0043; 0046; 0047; 0050; 0051