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ChemicalBook CAS DataBase List N-Boc-L-homoserine Methyl Ester 4-Methylbenzenesulfonate
120042-09-3

N-Boc-L-homoserine Methyl Ester 4-Methylbenzenesulfonate synthesis

3synthesis methods
-

Yield:120042-09-3 7.8 g

Reaction Conditions:

with dmap;triethylamine in dichloromethane at 0 - 20; for 2 h;

Steps:

7.1 step 1:

Dissolve SMA24 (4.66g), TEA (2.42g), DMAP (0.24g) in DCM (50mL),The temperature was lowered to 0° C., TsCl (4 g) was added in batches, and then reacted at room temperature for 2 hours. Water (30 mL) was added, the liquids were separated, and the organic phase was spin-dried to obtain 7.8 g of the product.

References:

CN112552348,2021,A Location in patent:Paragraph 0379-0384

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