5-BROMO-2-CHLORO-N,N-DIMETHYL-3-PYRIDINECARBOXAMIDE synthesis

4synthesis methods

Product Name:5-BROMO-2-CHLORO-N,N-DIMETHYL-3-PYRIDINECARBOXAMIDE
CAS Number:1188142-86-0
Molecular formula:C8H8BrClN2O
Molecular Weight:263.52

506-59-2 Synthesis

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5-BROMO-2-CHLORO-N,N-DIMETHYL-3-PYRIDINECARBOXAMIDE

1188142-86-0
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Yield:-

Reaction Conditions:

Stage #1: 5-bromo-2-hydroxynicotinic acidwith thionyl chloride;N,N-dimethyl-formamide at 80; for 4 h;
Stage #2: N,N-dimethylammonium chloride in dichloromethane;

Steps:

1

To a solution of compound 1 (3.0 g,) in SOCl₂ (15 mL) at rt was added DMF (0.75 mL) slowly. The mixture was then refluxed at 80 °C for 4 hrs. The solvent was removed under reduced pressure and the residue was dissolved in CH₂C1₂ (20 mL). Then the residue was dimethylamine hydrochloride (2.25 g,) was added in one portion. After addition of amine at 0 °C (11.5 mL), the reaction mixture was stirred overnight. The mixture was washed with water. The organic layer was separated and concentrated under vacuum to get desired compound 2

References:

WO2013/42035,2013,A1 Location in patent:Page/Page column 24

506-59-2 Synthesis

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78686-86-9 Synthesis