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ChemicalBook CAS DataBase List 4-(2-chloro-4-pyrimidinyl)benzoic acid methyl ester
1026029-33-3

4-(2-chloro-4-pyrimidinyl)benzoic acid methyl ester synthesis

1synthesis methods
3934-20-1 Synthesis
2,4-Dichloropyrimidine

3934-20-1
720 suppliers
$9.00/1g

99768-12-4 Synthesis
4-(METHOXYCARBONYL)PHENYLBORONIC ACID

99768-12-4
369 suppliers
$10.00/1g

4-(2-chloro-4-pyrimidinyl)benzoic acid methyl ester

1026029-33-3
19 suppliers
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Yield:1026029-33-3 85%

Reaction Conditions:

with bis-triphenylphosphine-palladium(II) chloride;sodium carbonate in 1,4-dioxane;water;N,N-dimethyl-formamide at 80; for 10 h;Inert atmosphere;

References:

Bliss, Brian I.;Ahmed, Feryan;Iyer, Subashree;Lin, Weimin;Walker, Joel;Zhao, He [Tetrahedron Letters,2010,vol. 51,# 25,p. 3259 - 3262] Location in patent:supporting information; experimental part