ChemicalBook CAS DataBase List 1-PHENYLCYCLOHEXANOL

1-PHENYLCYCLOHEXANOL synthesis

12synthesis methods

Product Name:1-PHENYLCYCLOHEXANOL
CAS Number:1589-60-2
Molecular formula:C12H16O
Molecular Weight:176.25

108-86-1 Synthesis

108-86-1
507 suppliers
$10.00/5g

108-94-1 Synthesis

108-94-1
544 suppliers
$12.00/50g

1589-60-2
109 suppliers
$47.67/10g

Yield:1589-60-2 97%

Reaction Conditions:

Stage #1: bromobenzenewith magnesium in diethyl ether at 35;
Stage #2: cyclohexanone in diethyl ether at 35; for 5 h;

Steps:

1.a a. Preparation of 1-phenylcyclohexanol.

Add bromobenzene (50g, .31mol), magnesium bar (8.13g, 0.33mol) in a 1000mL three-necked flask and dissolve in an appropriate amount 6 In the ether, it is triggered at 35°C. After the reaction is complete, add cyclohexanone (34.38g, 0.35mol), and react at 35°C. After 5 hours, TLC monitors the progress of the reaction. After the reaction is complete, add the reaction solution to a saturated aqueous solution of ammonium chloride, and use ether After extraction, the extract is dried and evaporated under reduced pressure to obtain the product. The yield is 97.0%.

References:

CN112939864,2021,A Location in patent:Paragraph 0050-0052

591-50-4 Synthesis