1-PHENYL-1-PENTYNE synthesis
- Product Name:1-PHENYL-1-PENTYNE
- CAS Number:4250-81-1
- Molecular formula:C11H12
- Molecular Weight:144.21
Yield: 75%
Reaction Conditions:
with iron(III) chloride;oxygen;copper diacetate;sodium acetate;lithium carbonate in 1,4-dioxane under 760.051 Torr; for 12 h;Schlenk technique;Heating;
Steps:
5 The implementation of the [...] 2 - (propyl -1 - alkynyl) benzene (3 de)
In one atmospheric pressure oxygen or air atmosphere, to the 15 ml Schlenk reaction tube by sequentially adding a phenylsulfonyl benzenesulfonyl jing compound 1 d (37.2 mg, 0 . 20 mmol), terminal alkyne 2 e (20 μl, 0 . 40 mmol), ferric chloride (1.7 mg, 0 . 001 mmol) or copper acetate (2.0 mg, 0 . 001 mmol), lithium carbonate (15 mg, 0 . 20 mmol), sodium acetate (17.0 mg, 0 . 20 mmol), 1, 4 - dioxane (1, 4 - dioxane, 1 ml), at a temperature of 110 °C reaction in 12 hours. After the reaction cooled to room temperature, the silicon after filtering algae earth, concentrated to obtain crude product. The crude product is used for the preparation of chromatography silica gel chromatographic separation, the selected developing agent or eluting agent is petroleum ether and ethyl acetate volume ratio of 100:1, to obtain the product 2 - (propyl -1 - alkynyl) naphthalene (3 de): yellow liquid, yield 75% (19.3 mg).
References:
Guangdong University of Technology;Li Xianwei;Wu Guocai;Huo Yanping CN108840785, 2018, A Location in patent:Paragraph 0079-0081
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