1-Phenyl-1-cyclohexanecarbonitrile synthesis
- Product Name:1-Phenyl-1-cyclohexanecarbonitrile
- CAS Number:2201-23-2
- Molecular formula:C13H15N
- Molecular Weight:185.26
Yield: 89.5%
Reaction Conditions:
Stage #1:phenylacetonitrile with sodium hydride in N,N-dimethyl-formamide at 0; for 0.5 h;
Stage #2:1,5-dibromo-pentane in N,N-dimethyl-formamide at 20; for 4 h;
Steps:
49 Synthesis of 1-phenylcyclohexane-1-nitrile (49A)
Dissolve NaH (2.05g, 85.36mmol) in DMF (10mL), slowly add benzylacetonitrile (2.00g, 17.07mmol) dropwise at 0, stir for 0.5h, add 1,5-dibromopentane (3.93g , 17.07mmol), react at room temperature for 4h, add 80mL water, extract with ethyl acetate (25mL×4), combine the organic layers, wash with saturated brine, dry with anhydrous magnesium sulfate, filter with suction, concentrate under reduced pressure, and separate and purify by column chromatography , To obtain 2.83 g of colorless oil, yield 89.5%
References:
CN113061098, 2021, A Location in patent:Paragraph 0399-0402
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