ChemicalBook CAS DataBase List 1-Octanesulfonyl Chloride

1-Octanesulfonyl Chloride synthesis

9synthesis methods

Product Name:1-Octanesulfonyl Chloride
CAS Number:7795-95-1
Molecular formula:C8H17ClO2S
Molecular Weight:212.74

A mixture of thiol (1 mmol), 30 percent H2O2 (3 mmol, 0.3 mL), and TiCl4 (1 mmol, 0.11 mL) was stirred in CH3CN at 25 °C for the time indicated in refPreviewPlaceHolderTable 1. A white solid (TiO2) immediately precipitated. After completion of the reaction as indicated by TLC, the mixture was quenched by adding H2O (10 mL), extracted with EtOAc (4 .x. 5 mL), and the extract was dried over anhydrous MgSO4. The filtrate was evaporated under a vacuum to afford the analytically pure product 1-Octanesulfonyl Chloride.

Carbamimidothioic acid,octyl ester, monohydrobromide (9CI)

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7795-95-1
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Yield:7795-95-1 95%

Reaction Conditions:

with tert-butylhypochlorite in water;acetonitrile at 0 - 20;

Steps:

Sulfonyl Chlorides 3; General Procedure

General procedure: Alkyl halide (or sulfate) (5 mmol) and thiourea (0.381 g, 5 mmol) were heated at reflux in EtOH (5 mL) for 1 h. After removal of the solvent in vacuum and washing with Et₂O (3 × 5 mL), the corresponding S-alkyl isothiourea salt was obtained as a white solid in almost quantitative yield. Without purification, the product was transferred into a three-necked round-bottom flask equipped with a thermometer and an addition funnel in an ice-bath, followed by addition of water (0.45mL) and MeCN (10 mL). To the resultant vigorously stirred mixture was added dropwise a solution of t-BuOCl (2.86 mL) in MeCN (5 mL), keeping the inner temperature at 0-20 °C. The mixture was then stirred for 30 min. Removal of the solvent under vacuum, addition of Et₂O (15 mL), washing with H₂O (2 × 10 mL), drying over Na₂SO₄, and concentration under vacuum gave the desired product in high purity. The product was further purified by recrystalization from petroleum ether-EtOAc.

References:

Qiu, Kui;Wang, Rennan [Synthesis,2015,vol. 47,# 20,art. no. SS-2015-H0078-OP,p. 3186 - 3190]