ChemicalBook CAS DataBase List 1-methyl-2,3-dihydroquinolin-4(1H)-one

1-methyl-2,3-dihydroquinolin-4(1H)-one synthesis

8synthesis methods

Product Name:1-methyl-2,3-dihydroquinolin-4(1H)-one
CAS Number:1198-15-8
Molecular formula:C10H11NO
Molecular Weight:161.2

4295-36-7
155 suppliers
$30.00/250mg

74-88-4
349 suppliers
$15.00/10g

1198-15-8
19 suppliers
$120.00/100mg

Yield:1198-15-8 68%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 80;

Steps:

42.1 Step 1

A mixture of compound 1 (2.0 g, 13.6 mmol), iodomethane (5.8 g. 40.8 mmoi), and K2C03 (5.5 g, 40.8 mmoi) in DMF (30 ml) was stirred at 80°C overnight. Tothe mixture was added EA (100 ml) and aqueous saturated NaC1 (100 ml), and the resulting reaction mixture was stilTed for 30 nun. The organic layer was separated, washed by aqueous saturated NaC1 (50 mi*2), dried and concentrated, purified by silica gel column to afford compound 2 (1.5 g, 68%) as a yellow solid.

References:

WO2016/94824,2016,A1 Location in patent:Page/Page column 80; 81

94-34-8 Synthesis