ChemicalBook CAS DataBase List 1-METHOXY-4-(METHYLTHIO)BENZENE

1-METHOXY-4-(METHYLTHIO)BENZENE synthesis

11synthesis methods

Product Name:1-METHOXY-4-(METHYLTHIO)BENZENE
CAS Number:1879-16-9
Molecular formula:C8H10OS
Molecular Weight:154.23

624-92-0 Synthesis

624-92-0
325 suppliers
$20.62/5 mL

696-62-8
348 suppliers
$5.00/1g

1879-16-9
123 suppliers
$10.00/1g

Yield:1879-16-9 78%

Reaction Conditions:

with tetrabutylammomium bromide;copper(II) acetate monohydrate;potassium hydroxide in water at 100; for 12 h;Catalytic behavior;Sealed tube;Reagent/catalyst;Temperature;

Steps:

(Het)aryl Methyl Sulfides; General Procedure
General procedure: A 25-mL sealable tube was charged with the appropriate aryliodide or bromide (1.0 mmol), dimethyl disulfide (1.2 mmol),Cu(OAc)2·H2O (0.1 mmol), KOH (2.0 mmol), TBAB (0.05 mmol),and H2O (2.0 mL). The mixture was stirred at 100 °C (130 °C forbromides) for 12 h under air then cooled to r.t. The mixture wasdiluted with H2O (5 mL) and extracted with EtOAc (4 × 10 mL).The extracts were combined, washed with brine (3 × 10 mL),dried (MgSO4), filtered, and concentrated. The residue was purifiedby chromatography [silica gel, EtOAc–hexane (1:30 to1:100)].

References:

Wang, Ying-Yu;Wu, Xiang-Mei;Yang, Ming-Hua [Synlett,2020] Location in patent:supporting information

624-92-0 Synthesis

624-92-0
325 suppliers
$20.62/5 mL

104-94-9 Synthesis