1-FURAN-2-YLMETHYL-PIPERAZINE synthesis

4synthesis methods

Product Name:1-FURAN-2-YLMETHYL-PIPERAZINE
CAS Number:59037-70-6
Molecular formula:C9H14N2O
Molecular Weight:166.22

110-85-0 Synthesis

110-85-0
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$5.00/5G

98-01-1 Synthesis

98-01-1
490 suppliers
$22.00/25g

59037-70-6
30 suppliers
$45.00/50mg

Yield:59037-70-6 58%

Reaction Conditions:

with sodium cyanoborohydride in acetic acid at 0 - 20; for 6 h;

Steps:

43.1

Step l0.5 g (5.2 mmol) of 2-furaldehyde was dissolved in acetic acid in a dried round flask provided with nitrogen gas, 2.24 g (26 mmol) of piperazine was added thereto, and 0.4 g (6.36 mmol, 1.2 eq) of sodium cyanoborohydride was slowly added thereto at 0 ^°C . After heating to room temperature, the reaction mixture was kept for 6 hrs, and concentrated under a reduced pressure to remove the solvent. The resulting solution was mixed with NaOH and extracted with dichloromethane. The formed organic layer was dried over anhydrous magnesium sulfate, and concentrated under a reduced pressure. The resulting residue was subjected to silica gel column chromatography (dichloromethane:methanol=4:l) to obtain l-((furan-2-yl)methyl)piperazine (yield:58%).

References:

WO2008/153325,2008,A1 Location in patent:Page/Page column 78