1-Cyclohexylpiperazine synthesis
- Product Name:1-Cyclohexylpiperazine
- CAS Number:17766-28-8
- Molecular formula:C10H20N2
- Molecular Weight:168.28
1224935-95-8
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17766-28-8
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Yield:17766-28-8 90.1%
Reaction Conditions:
with hydrogenchloride in ethanol;water at 20; for 18 h;
Steps:
A solution of comp A0023-2 (1.38 g, 5.15 mmol) in ethanol/hydrochloric acid (15 mL) was stirred overnight (about 18 hours) at room temperature. Then, the solvent was removed and 5 mL of H2O was added into the mixture. The mixture was washed with ethyl acetate (5 ml x 3) and the aqueous phase was neutralized to pH=7~8 and extracted with ethyl acetate (10 ml x 3) . The combined organic phase was dried and concentrated and to yield 0.78 g of the title product (LC-MS and TLC confirmed, yield: 90.1%) .
References:
WO2010/51374,2010,A1 Location in patent:Page/Page column 84; 85
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17766-28-8
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